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Intermittent Fasting and The Enteric Nervous System: Gut Health and Fasting

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Intermittent fasting has gained popularity in recent years as a method for weight loss and improving overall health. It involves alternating periods of fasting and eating, with the most common approach being a daily fasting window of 16 hours and an eating window of 8 hours. While the benefits of intermittent fasting on weight loss and metabolic health have been extensively studied, its effects on the enteric nervous system and gut health are less well-known. In this article, we will explore the relationship between intermittent fasting and the enteric nervous system, and how fasting can impact gut health.

The Enteric Nervous System: An Overview

The enteric nervous system (ENS) is often referred to as the “second brain” of the body. It is a complex network of neurons that controls the function of the gastrointestinal tract. The ENS is responsible for regulating digestion, nutrient absorption, and gut motility. It communicates with the central nervous system (CNS) through the vagus nerve, but it can also function independently, allowing it to control gut function even when disconnected from the CNS.

The ENS contains over 100 million neurons, which is more than the spinal cord. It is composed of two main plexuses: the myenteric plexus, which is located between the layers of smooth muscle in the gut wall, and the submucosal plexus, which is found in the submucosa. These plexuses work together to coordinate the movement of food through the digestive system and regulate the secretion of digestive enzymes and hormones.

Intermittent Fasting and Gut Health

Intermittent fasting has been shown to have several positive effects on gut health. Here are some ways in which fasting can benefit the gut:

  • Improved gut motility: Fasting has been found to increase the frequency and amplitude of contractions in the gastrointestinal tract, which can help improve gut motility. This can prevent constipation and promote regular bowel movements.
  • Enhanced gut barrier function: The gut barrier is a protective layer that prevents harmful substances from entering the bloodstream. Intermittent fasting has been shown to strengthen the gut barrier by increasing the production of tight junction proteins, which help maintain the integrity of the intestinal lining.
  • Reduced inflammation: Chronic inflammation in the gut is associated with various digestive disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Studies have shown that intermittent fasting can reduce inflammation in the gut by suppressing the production of pro-inflammatory cytokines.
  • Increased diversity of gut microbiota: The gut microbiota plays a crucial role in maintaining gut health. Intermittent fasting has been found to increase the diversity of gut microbiota, which is associated with improved digestion, nutrient absorption, and overall gut health.
  • Promotion of autophagy: Autophagy is a cellular process that involves the recycling of damaged or dysfunctional cellular components. It helps remove toxins and maintain cellular health. Intermittent fasting has been shown to stimulate autophagy in the gut, which can help eliminate damaged cells and promote tissue repair.

The Role of the Circadian Rhythm

The circadian rhythm, also known as the body’s internal clock, plays a significant role in the regulation of gut function. It controls various physiological processes, including digestion and nutrient absorption. Intermittent fasting can help align the eating patterns with the circadian rhythm, which can optimize gut health.

Research has shown that the gut microbiota follows a circadian rhythm, with different microbial species exhibiting peak activity at specific times of the day. Disruptions in the circadian rhythm, such as irregular eating patterns or late-night eating, can negatively impact the gut microbiota and lead to gut dysbiosis.

Intermittent fasting can help regulate the circadian rhythm by establishing a consistent eating pattern. By restricting the eating window to a specific time frame, intermittent fasting ensures that the gut microbiota receives regular signals and can function optimally. This can help maintain a healthy balance of gut bacteria and promote overall gut health.

Intermittent Fasting and Gut-Brain Axis

The gut-brain axis is a bidirectional communication system between the gut and the brain. It involves the ENS, the CNS, and the gut microbiota. The gut-brain axis plays a crucial role in regulating various physiological processes, including digestion, mood, and cognition.

Intermittent fasting has been found to influence the gut-brain axis in several ways:

  • Regulation of neurotransmitters: Fasting has been shown to increase the production of brain-derived neurotrophic factor (BDNF), a protein that promotes the growth and survival of neurons. BDNF is involved in various brain functions, including learning, memory, and mood regulation.
  • Reduction of oxidative stress: Oxidative stress is a condition characterized by an imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defenses. It can lead to inflammation and damage to neurons. Intermittent fasting has been shown to reduce oxidative stress in the brain, which can protect against neurodegenerative diseases.
  • Modulation of gut hormones: Fasting can affect the secretion of gut hormones, such as ghrelin and leptin, which regulate appetite and energy balance. Studies have shown that intermittent fasting can improve insulin sensitivity and reduce the risk of obesity and metabolic disorders.
  • Impact on gut microbiota: The gut microbiota plays a crucial role in the production of neurotransmitters and the regulation of brain function. Intermittent fasting has been found to modulate the composition of gut microbiota, which can influence brain health and cognitive function.


Intermittent fasting has emerged as a popular dietary approach for weight loss and improving overall health. While its effects on weight loss and metabolic health are well-documented, its impact on the enteric nervous system and gut health is less understood. However, emerging research suggests that intermittent fasting can have several positive effects on gut health, including improved gut motility, enhanced gut barrier function, reduced inflammation, increased diversity of gut microbiota, and promotion of autophagy.

Furthermore, intermittent fasting can help regulate the circadian rhythm and optimize the function of the gut microbiota. It also influences the gut-brain axis, affecting neurotransmitter production, oxidative stress levels, gut hormone secretion, and the composition of gut microbiota.

Overall, intermittent fasting appears to be a promising approach for promoting gut health. However, further research is needed to fully understand the mechanisms underlying its effects on the enteric nervous system and gut health. In the meantime, incorporating intermittent fasting into a balanced and healthy lifestyle may offer potential benefits for gut health and overall well-being.

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